Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+,K(+)-ATPase distributions in polarized epithelia

@article{Marrs1993DistinguishingRO,
  title={Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+,K(+)-ATPase distributions in polarized epithelia},
  author={James A Marrs and E W Napolitano and C Murphy-Erdosh and Robert W. Mays and Louis French Reichardt and Ward Nelson},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={123},
  pages={149 - 164}
}
In simple epithelia, the distribution of ion transporting proteins between the apical or basal-lateral domains of the plasma membrane is important for determining directions of vectorial ion transport across the epithelium. In the choroid plexus, Na+,K(+)-ATPase is localized to the apical plasma membrane domain where it regulates sodium secretion and production of cerebrospinal fluid; in contrast, Na+,K(+)-ATPase is localized to the basal-lateral membrane of cells in the kidney nephron where it… CONTINUE READING
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