Distinguishing protein-coding and noncoding genes in the human genome.

  title={Distinguishing protein-coding and noncoding genes in the human genome.},
  author={Michele Clamp and B. Fry and Mike Kamal and Xiaohui Xie and James Cuff and Michael F. Lin and Manolis Kellis and Kerstin Lindblad-Toh and Eric S. Lander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 49},
Although the Human Genome Project was completed 4 years ago, the catalog of human protein-coding genes remains a matter of controversy. Current catalogs list a total of approximately 24,500 putative protein-coding genes. It is broadly suspected that a large fraction of these entries are functionally meaningless ORFs present by chance in RNA transcripts, because they show no evidence of evolutionary conservation with mouse or dog. However, there is currently no scientific justification for… CONTINUE READING
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