Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysis

@inproceedings{Merid2014DistinguishingBD,
  title={Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysis},
  author={Simon Kebede Merid and Daria Goranskaya and Andrey Alexeyenko},
  booktitle={BMC Bioinformatics},
  year={2014}
}
In somatic cancer genomes, delineating genuine driver mutations against a background of multiple passenger events is a challenging task. The difficulty of determining function from sequence data and the low frequency of mutations are increasingly hindering the search for novel, less common cancer drivers. The accumulation of extensive amounts of data on somatic point and copy number alterations necessitates the development of systematic methods for driver mutation analysis. We introduce a… CONTINUE READING
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