Distinguishing between anti-platelet factor 4/heparin antibodies that can and cannot cause heparin-induced thrombocytopenia.

@article{Nazi2015DistinguishingBA,
  title={Distinguishing between anti-platelet factor 4/heparin antibodies that can and cannot cause heparin-induced thrombocytopenia.},
  author={Ishac Nazi and D. Arnold and Theodore E Warkentin and J. Warren Smith and Phillip Staibano and John G. Kelton},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2015},
  volume={13 10},
  pages={
          1900-7
        }
}
BACKGROUND Many patients exposed to heparin develop antibodies against platelet factor 4 (PF4) and heparin, yet only those antibodies that activate platelets cause heparin-induced thrombocytopenia (HIT). Patients who produce anti-PF4/heparin antibodies without developing HIT either have antibodies that do not cause platelet activation or produce pathogenic antibodies at levels that are insufficient to cause HIT. Understanding the differences between anti-PF4/heparin antibodies with and without… CONTINUE READING

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