Distinguishing aggregate formation and aggregate clearance using cell-based assays.

@article{Eenjes2016DistinguishingAF,
  title={Distinguishing aggregate formation and aggregate clearance using cell-based assays.},
  author={Evelien Eenjes and Joanna M. Dragich and Harm H. Kampinga and Ai Yamamoto},
  journal={Journal of cell science},
  year={2016},
  volume={129 6},
  pages={1260-70}
}
The accumulation of ubiquitylated proteinaceous inclusions represents a complex process, reflecting the disequilibrium between aggregate formation and aggregate clearance. Although decreasing aggregate formation or augmenting aggregate clearance will ultimately lead to a diminished aggregate burden, in terms of disease pathogenesis, the different approaches can have distinct outcomes. Using a novel cell-based assay that can distinguish newly formed versus preformed inclusions, we demonstrate… CONTINUE READING