Distinguishable In Vitro Binding Mode of Monomeric TRBP and Dimeric PACT with siRNA

@inproceedings{Takahashi2013DistinguishableIV,
  title={Distinguishable In Vitro Binding Mode of Monomeric TRBP and Dimeric PACT with siRNA},
  author={Tomoko Tazawa Takahashi and Takuya Miyakawa and Shuhei Zenno and Kenji Nishi and Masaru Tanokura and Kumiko Ui-Tei},
  booktitle={PloS one},
  year={2013}
}
RNA interference (RNAi) is an evolutionally conserved posttranscriptional gene-silencing mechanism whereby small interfering RNA (siRNA) triggers sequence-specific cleavage of its cognate mRNA. Dicer, Argonaute (Ago), and either TAR-RNA binding protein (TRBP) or a protein activator of PKR (PACT) are the primary components of the RNAi pathway, and they comprise the core of a complex termed the RNA-induced silencing complex (RISC)-loading complex (RLC). TRBP and PACT share similar structural… CONTINUE READING
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