Distinctive tissue distribution and phosphorylation of IRSp53 isoforms.

@article{OkamuraOho2001DistinctiveTD,
  title={Distinctive tissue distribution and phosphorylation of IRSp53 isoforms.},
  author={Yuko Okamura-Oho and Toshiyuki Miyashita and Mitsuhiko Yamada},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={289 5},
  pages={957-60}
}
An insulin-receptor substrate of 53-kDa protein (IRSp53) is an adapter protein, which interacts with the Rho-family of GTPases and mediates neurite outgrowth. It also binds to DRPLA protein, a product of the gene responsible for a polyglutamine disease, dentatorubral-pallidoluysian atrophy (DRPLA). Isoforms of human IRSp53 have been reported, each with a… CONTINUE READING