Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory.

@article{Tronson2012DistinctiveRF,
  title={Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory.},
  author={Natalie C Tronson and Shari L Wiseman and Rachael Lee Neve and Eric J Nestler and Peter Olausson and Jane Rebecca Taylor},
  journal={Learning & memory},
  year={2012},
  volume={19 5},
  pages={178-81}
}
Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear… CONTINUE READING