Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions.

@article{Penteado2017DistinctiveRO,
  title={Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions.},
  author={Let{\'i}cia de Aquino Penteado and Naiara N Dejani and Felipe Fortino Verdan and Allan Botinhon Orlando and Victoria Eugenia Ni{\~n}o and Fernanda De Nuzzi Dias and Ana Carolina Guerta Salina and Alexandra Ivo Medeiros},
  journal={Immunology},
  year={2017},
  volume={151 3},
  pages={
          304-313
        }
}
Efferocytosis, or clearance of apoptotic cells (ACs), by dendritic cells (DCs) leads to immune response suppression and tolerance to self-antigens. However, efferocytosis of infected apoptotic cells (IACs) leads to the production of a mixed pro- and anti-inflammatory cytokine milieu. We examined the DC phenotype and ability to migrate after phagocytosis of ACs or IACs and observed higher levels of CD86 and CCR7 expression in DCs, as well as enhanced migration capacity following efferocytosis of… CONTINUE READING
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