Distinctive properties of the 5'-untranslated region of human hsp70 mRNA.

  title={Distinctive properties of the 5'-untranslated region of human hsp70 mRNA.},
  author={Maria Rubtsova and Daria V Sizova and Sergei E. Dmitriev and Dmitri S Ivanov and Vladimir S. Prassolov and Ivan N Shatsky},
  journal={The Journal of biological chemistry},
  volume={278 25},
A relaxed cap-dependence of translation of the mRNA-encoding mammalian heat shock protein Hsp70 may suggest that its 5'-untranslated region (UTR) possesses an internal ribosome entry site (IRES). In this study, this possibility has been tested in transfected cells using plasmids that express dicistronic mRNAs. Using a reporter gene construct, Renilla luciferase/Photinus pyralis luciferase, we show that the 216-nt long 5'-UTR of Hsp70 mRNA acts as an IRES that directs ribosomes to the downstream… CONTINUE READING


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Translational Control (Hershey

  • R. F. Duncan
  • 1996
1 Excerpt

398–414 IRES-properties of the 5 -UTR of Hsp70 mRNA

  • E. V. Pilipenko, A. P. Gmyl, +5 authors V. I. Agol
  • J. Mol. Biol
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1 Excerpt

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