Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing.

@article{Zvyagin2014DistinctivePO,
  title={Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing.},
  author={Ivan Zvyagin and Mikhail V Pogorelyy and Marina E. Ivanova and Ekaterina Komech and Mikhail Shugay and D. A. Bolotin and Andrey A. Shelenkov and Alexey A. Kurnosov and Dmitriy B Staroverov and Dmitriy M Chudakov and Yuri B. Lebedev and Ilgar Z. Mamedov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 16},
  pages={5980-5}
}
Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface of B and T cells. The final set of these molecules in each organism is formed under the influence of two forces: individual genetic traits and the environment, which includes the diverse spectra of alien and self-antigens. Here we assess the impact of individual genetic factors on the formation of the adaptive immunity by analyzing the T-cell receptor (TCR) repertoires of three pairs of monozygous twins by… CONTINUE READING
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