Distinctive patterns of Her-2/neu, c-myc, and cyclin D1 gene amplification by fluorescence in situ hybridization in primary human breast cancers.

@article{Janocko2001DistinctivePO,
  title={Distinctive patterns of Her-2/neu, c-myc, and cyclin D1 gene amplification by fluorescence in situ hybridization in primary human breast cancers.},
  author={Laura E. Janocko and Kathryn A. Brown and Charles A. Smith and Lianping Gu and Agnese A. Pollice and Sarita G. Singh and Thomas Julian and Norman Wolmark and Lillian Sweeney and Jan F. Silverman and Stanley Shackney},
  journal={Cytometry},
  year={2001},
  volume={46 3},
  pages={136-49}
}
BACKGROUND Human solid tumors undergo clonal evolution as they progress, but evidence for specific sequences of genetic changes that occur in individual tumors and are recapitulated in other tumors is difficult to obtain. METHODS Patterns of amplification of Her-2/neu, c-myc, and cyclin D1 were determined by fluorescence in situ hybridization (FISH) in relation to the presence of p53 dysfunction and ploidy in 60 primary human breast cancers. RESULTS We show that there are clusters of… CONTINUE READING
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