Distinctive origin of artemisinin-resistant Plasmodium falciparum on the China-Myanmar border

@inproceedings{Ye2016DistinctiveOO,
  title={Distinctive origin of artemisinin-resistant Plasmodium falciparum on the China-Myanmar border},
  author={Run Ye and Dongwei Hu and Yilong Zhang and Yufu Huang and Xiaodong Sun and Jian Wang and Xuedi Chen and Hongning Zhou and Dongmei Zhang and Mathirut Mungthin and Weiqing Pan},
  booktitle={Scientific reports},
  year={2016}
}
The artemisinin (ART), discovered in China, has been widely used against malaria in China over the last 30 years. Understanding the emergence and origin of ART resistance in China is therefore of great interest. We analyzed 111 culture-adapted isolates of P. falciparum from China-Myanmar (CM) border for their susceptibility to dihydroartemisinin using the ring stage survival assay (RSA0-3h) and genotyped their K13 genes. Of the isolates, 59 had a wild type of the K13 marker and a median ring… CONTINUE READING
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