Distinctive in vivo kinetics of the new σ1 receptor ligands (R)-(+)- and (S)-(-)-18F-fluspidine in porcine brain.

Abstract

UNLABELLED Because of their involvement in growth and survival signaling cascades, the σ(1) receptors (σ(1)Rs) represent a novel target for the treatment of cancer and several brain diseases such as depression and neurodegeneration. From a series of σ1R-specific (18)F-fluoroalkylated spirocyclic piperidines, we have chosen (18)F-fluspidine for detailed… (More)
DOI: 10.2967/jnumed.114.137562

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@article{Brust2014DistinctiveIV, title={Distinctive in vivo kinetics of the new σ1 receptor ligands (R)-(+)- and (S)-(-)-18F-fluspidine in porcine brain.}, author={Peter Brust and Winnie Deuther-Conrad and Georg A. Becker and Marianne Patt and Cornelius Kurt Donat and Shannon Stittsworth and Steffen Fischer and Achim Hiller and Barbara Wenzel and Sladjana Dukic-Stefanovic and Swen Hesse and J{\"{o}rg Steinbach and Bernhard W{\"{u}nsch and Susan Zemyan Lever and Osama Sabri}, journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year={2014}, volume={55 10}, pages={1730-6} }