Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

@inproceedings{Zhou2018DistinctiveEC,
  title={Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues},
  author={Dan Zhou and Bonnie M. Alver and Shuang Li and Ryan A. Hlady and Joyce J. Thompson and Mark A Schroeder and Jeong-Heon Lee and Jingxin Qiu and Philip Hitchins Schwartz and Jann N. Sarkaria and Keith D. Robertson},
  booktitle={Genome Biology},
  year={2018}
}
Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC population may improve patient survival, but unique vulnerabilities need to be identified. We isolate GSCs from well-characterized GBM patient-derived xenografts (PDX), characterize their stemness properties using immunofluorescence staining, profile their epigenome including 5mC, 5hmC… CONTINUE READING
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GEO data series, accession GSE92469: Characterizing the epigenome of glioma stem cells

  • D Zhou, KD Robertson
  • 2018
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