Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

@article{Iwasaki2005DistinctiveAI,
  title={Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.},
  author={Hiromi Iwasaki and Chamorro Somoza and Hirokazu Shigematsu and Estelle A Duprez and Junko Iwasaki-Arai and Shin-ichi Mizuno and Yojirou Arinobu and K. Geary and Pu Zhang and Tajhal Dayaram and Maris L Fenyus and Shannon Elf and Susan Chan and Philippe Kastner and Claudia S. Huettner and Richard Murray and Daniel G Tenen and Koichi Akashi},
  journal={Blood},
  year={2005},
  volume={106 5},
  pages={1590-600}
}
The PU.1 transcription factor is a key regulator of hematopoietic development, but its role at each hematopoietic stage remains unclear. In particular, the expression of PU.1 in hematopoietic stem cells (HSCs) could simply represent "priming" of genes related to downstream myelolymphoid lineages. By using a conditional PU.1 knock-out model, we here show that HSCs express PU.1, and its constitutive expression is necessary for maintenance of the HSC pool in the bone marrow. Bone marrow HSCs… CONTINUE READING
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B cell development in the absence of PU.1 [abstract

  • M Ye, O Ermaermakova-Cirilli, T. Graf
  • Blood
  • 2004

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