Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain.

@article{Xu2010DistinctiveRE,
  title={Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain.},
  author={Huichun Xu and Boryana S Stamova and Glen C. Jickling and Yingfang Tian and Xin-hua Zhan and Bradley P. Ander and Dazhi Liu and Ren{\'e}e Jade Turner and Jonathan Rosand and Larry B. Goldstein and Karen L. Furie and Piero Verro and S C Johnston and Frank R. Sharp and Charles S Decarli},
  journal={Stroke},
  year={2010},
  volume={41 12},
  pages={2744-9}
}
BACKGROUND AND PURPOSE White matter hyperintensities (WMH) are areas of high signal detected by T2 and fluid-attenuated inversion recovery sequences on brain MRI. Although associated with aging, cerebrovascular risk factors, and cognitive impairment, the pathogenesis of WMH remains unclear. Thus, RNA expression was assessed in the blood of individuals with and without extensive WMH to search for evidence of oxidative stress, inflammation, and other abnormalities described in WMH lesions in… CONTINUE READING