Distinctive Behaviors of Druggable Proteins in Cellular Networks

@inproceedings{Mitsopoulos2015DistinctiveBO,
  title={Distinctive Behaviors of Druggable Proteins in Cellular Networks},
  author={Costas Mitsopoulos and Amanda C. Schierz and Paul Workman and Bissan Al-Lazikani},
  booktitle={PLoS Computational Biology},
  year={2015}
}
The interaction environment of a protein in a cellular network is important in defining the role that the protein plays in the system as a whole, and thus its potential suitability as a drug target. Despite the importance of the network environment, it is neglected during target selection for drug discovery. Here, we present the first systematic, comprehensive computational analysis of topological, community and graphical network parameters of the human interactome and identify discriminatory… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Similar Papers

Loading similar papers…