Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

@article{Budd1987DistinctionOV,
  title={Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.},
  author={Ralph C. Budd and Jean Charles Cerottini and Curt M Horvath and Claude Bron and Thierry Pedrazzini and Rawleigh C. Howe and H Robson Macdonald},
  journal={Journal of immunology},
  year={1987},
  volume={138 10},
  pages={3120-9}
}
The Pgp-1 glycoprotein was identified on a minor (27%) subset of peripheral Lyt-2+ or L3T4+ T cells. In contrast, mature medullary-type thymocytes (Lyt-2+ L3T4-, Lyt-2- L3T4+) were nearly devoid of cells expressing detectable surface Pgp-1. The appearance of peripheral Pgp-1- T cells was found to be thymus dependent, as demonstrated by the diminished proportion of Pgp-1- T cells after thymectomy and their virtual absence in athymic nude mice. The subsequent acquisition of surface Pgp-1 was… CONTINUE READING
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