Distinction of nephroblastomas from other childhood tumors using antibodies to intermediate filaments.

@article{Altmannsberger1984DistinctionON,
  title={Distinction of nephroblastomas from other childhood tumors using antibodies to intermediate filaments.},
  author={Michael Altmannsberger and Mary Osborn and H W Schaefer and Alfred Schauer and Klaus -Josef Weber},
  journal={Virchows Archiv. B, Cell pathology including molecular pathology},
  year={1984},
  volume={45 2},
  pages={113-24}
}
Ten nephroblastomas were investigated by antibodies to intermediate filaments. In seven cases, which in light microscopy were characterized by the presence of blastema and tubules, immunofluorescence microscopy with IF-specific antibodies reveals expression of cytokeratin and vimentin in blastema cells, while tubules were only labelled by the cytokeratin antibodies. This result was independent of whether the conventional cytokeratin antibody or monoclonal antibodies specific for cytokeratin 18… CONTINUE READING
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