Distinction between the in vitro and in vivo inhibitory effects of morphine on lymphocyte proliferation based on agonist sensitivity and naltrexone reversibility.

@article{Bayer1992DistinctionBT,
  title={Distinction between the in vitro and in vivo inhibitory effects of morphine on lymphocyte proliferation based on agonist sensitivity and naltrexone reversibility.},
  author={Barbara M. Bayer and Marc R. Gastonguay and Mar{\'i}a Concepci{\'o}n Hern{\'a}ndez},
  journal={Immunopharmacology},
  year={1992},
  volume={23 2},
  pages={117-24}
}
We have previously reported that administration of a single dose of morphine (25 mg/kg) to rats results in a naltrexone-sensitive suppression of mitogen-stimulated lymphocyte proliferation. To further delineate the site of action of this inhibitory effect, the in vitro and in vivo effects of morphine on mitogen-stimulated lymphocyte proliferation were examined. In vitro, concentrations of morphine exceeding 0.1 mM exhibited a dose-dependent inhibition of Concanavalin A-induced proliferation of… CONTINUE READING

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