Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability.

@article{Jass2002DistinctionBF,
  title={Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability.},
  author={Jereny R Jass and M. D. Walsh and Melissa L Barker and Lisa A. Simms and Joanne A. Young and Barbara A. Leggett},
  journal={European journal of cancer},
  year={2002},
  volume={38 7},
  pages={858-66}
}
Attempts to classify colorectal cancer into subtypes based upon molecular characterisation are overshadowed by the classical stepwise model in which the adenoma-carcinoma sequence serves as the morphological counterpart. Clarity is achieved when cancers showing DNA microsatellite instability (MSI) are distinguished as sporadic MSI-low (MSI-L), sporadic MSI-high (MSI-H) and hereditary non-polyposis colorectal cancer (HNPCC). Divergence of the 'methylator' pathway into MSI-L and MSI-H is at least… CONTINUE READING

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