Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases.

@article{Mayer2013DistinctionAT,
  title={Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases.},
  author={Marie Cathrin Mayer and Constanze Breithaupt and Markus Reindl and Kathrin Schanda and Kevin Rost{\'a}sy and Thomas F H Berger and Russell C Dale and Fabienne Brilot and Tomas Olsson and Dieter Jenne and Anne-Katrin Proebstel and Klaus Dornmair and Hartmut Wekerle and Reinhard Hohlfeld and Brenda Banwell and Amit Bar-Or and Edgar Meinl},
  journal={Journal of immunology},
  year={2013},
  volume={191 7},
  pages={3594-604}
}
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found in different inflammatory diseases of the CNS, but their antigenic epitopes have not been mapped. We expressed mutants of MOG on human HeLa cells and analyzed sera from 111 patients (104 children, 7 adults) who recognized cell-bound human MOG, but had… CONTINUE READING