Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.

@article{Thullberg2000DistinctVR,
  title={Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors.},
  author={M Thullberg and Jirina Bartkova and Sabina F. Khan and Klaus Hansen and Lars R{\"o}nnstrand and Jiri Lukas and Michael Strauss and Jiri Bartek},
  journal={FEBS letters},
  year={2000},
  volume={470 2},
  pages={161-6}
}
p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d) comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4… CONTINUE READING