Distinct ventral and dorsal hippocampus AP5 anxiolytic effects revealed in the elevated plus-maze task in rats

@article{Hckl2007DistinctVA,
  title={Distinct ventral and dorsal hippocampus AP5 anxiolytic effects revealed in the elevated plus-maze task in rats},
  author={Luciane Pereira Nascimento H{\"a}ckl and Antonio de P{\'a}dua Carobrez},
  journal={Neurobiology of Learning and Memory},
  year={2007},
  volume={88},
  pages={177-185}
}
The hippocampal formation (HPC) mediates processes associated with learning, memory, anxiety and fear. The glutamate N-methyl-d-aspartate (NMDA)-receptor subtype is involved in many HPC functional processes related to learning and memory. Although not tested for the HPC, NMDA-receptor antagonists reduced fear and anxiety related responses when applied to other brain regions mediating defensive behaviour. Consequently, this study evaluated the effects of ventral or dorsal HPC application of the… CONTINUE READING

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