Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.

@article{Matallanas2006DistinctUO,
  title={Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.},
  author={David Matallanas and Victoria Sanz-Moreno and Imanol Arozarena and Fernando Garcia Calvo and Lorena Agudo-Ib{\'a}{\~n}ez and Eugenio Santos and Mar{\'i}a Teresa Berciano and Piero Crespo},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 1},
  pages={100-16}
}
Ras proteins are distributed in different types of plasma membrane microdomains and endomembranes. However, how microlocalization affects the signals generated by Ras and its subsequent biological outputs is largely unknown. We have approached this question by selectively targeting RasV12 to different cellular sublocalizations. We show here that compartmentalization dictates Ras utilization of effectors and the intensity of its signals. Activated Ras can evoke enhanced proliferation and… CONTINUE READING

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Ras FUNCTIONS AT DISTINCT COMPARTMENTS 115 on Jauary 6, 2018 by gest hp://m c.asm .rg

  • O. A. Coso, M. Chiariello, +5 authors VOL
  • D ow nladed fom and J. S. Gutkind
  • 2006

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