Distinct types of tumor-initiating cells form human colon cancer tumors and metastases.

@article{Dieter2011DistinctTO,
  title={Distinct types of tumor-initiating cells form human colon cancer tumors and metastases.},
  author={Sebastian M Dieter and Claudia R Ball and Christopher M Hoffmann and Ali Nowrouzi and Friederike Herbst and Oksana Zavidij and Ulrich Abel and Anne Arens and Wilko Weichert and Karsten Brand and Moritz Koch and J{\"u}rgen Weitz and Manfred Schmidt and Christof von Kalle and Hanno Glimm},
  journal={Cell stem cell},
  year={2011},
  volume={9 4},
  pages={357-65}
}
Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population driving tumor maintenance and metastasis formation. We found unexpected cellular heterogeneity within the TIC compartment, which contains three types of TICs. Extensively self-renewing long-term TICs (LT-TICs) maintained tumor formation in serial xenotransplants. Tumor transient amplifying cells (T-TACs) with limited or no self-renewal… CONTINUE READING