Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

@article{Alizadeh2000DistinctTO,
  title={Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling},
  author={Ash A. Alizadeh and Michael B. Eisen and R. Eric Davis and Chishieva Ma and Izidore S. Lossos and Andreas Rosenwald and Jennifer C. Boldrick and Hajeer Sabet and T L N Tran and Xin Yu and John I. Powell and Liming Yang and Gerald Marti and Troy Moore and James I. Hudson and Li-Sheng Lu and David B. Lewis and Robert Tibshirani and Gavin Sherlock and Wing C. Chan and Timothy C Greiner and Dennis D. Weisenburger and James Olen Armitage and Roger A. Warnke and Ronald Levy and Wyndham H Wilson and Michael R Grever and John C. Byrd and David Botstein and Patrick O. Brown and Louis M. Staudt},
  journal={Nature},
  year={2000},
  volume={403},
  pages={503-511}
}
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. [] Key Result We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different stages of B-cell differentiation.
Gene Expression Profiling of Diffuse Large B-Cell Lymphoma
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B-cell differentiation, apoptosis and proliferation in diffuse large B-cell lymphomas.
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There has been accumulating molecular and immunohistochemical evidence indicating links between B-cell differentiation gene expression profiles and expression of apoptosis and cell cycle-associated genes in DLBCL.
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Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma subtype. In Sweden 450 new cases are diagnosed annually. With modern anthracycline-containing chemotherapy DLBCL is potentially
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  • 2013
Diffuse large B cell lymphoma: from gene expression profiling to prediction of outcome.
  • I. Lossos
  • Biology
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • 2008
Biological Pathways in B-cell Non-Hodgkin's Lymphoma
TLDR
It was found that high expression of TCL1 was related to poor prognosis in CLL and MCL in microarray and immunohistochemistry respectively, while they also define striking heterogeneity within known lymphoma types.
Molecular Characteristics of Diffuse Large B-cell Lymphoma, Not Otherwise Specified
TLDR
Gene profiling has identified “cell-of-origin” molecular subtypes of DLBCL based on expression patterns similar to normal B-cells, which will certainly impact routine diagnosis, classification, and therapeutic decisions.
Precision Treatment of Distinct Molecular Subtypes of Diffuse Large B-cell Lymphoma: Ascribing Treatment Based on the Molecular Phenotype
TLDR
This work offers the chance of improving the curability of DLBCL, particularly in the activated B-cell subtype, where standard approaches are inadequate for a high proportion of patients.
The biology of human lymphoid malignancies revealed by gene expression profiling.
...
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