Distinct troponin C isoform requirements in cardiac and skeletal muscle.

@article{Sogah2010DistinctTC,
  title={Distinct troponin C isoform requirements in cardiac and skeletal muscle.},
  author={Vanessa M Sogah and Fabrizio C. Serluca and Mark C Fishman and Deborah Yelon and Calum A. MacRae and John D. Mably},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2010},
  volume={239 11},
  pages={3115-23}
}
The zebrafish mutant silent partner is characterized by a dysmorphic, non-contractile ventricle resulting in an inability to generate normal blood flow. We have identified the genetic lesion in the zebrafish homolog of the slow twitch skeletal/cardiac troponin C gene. Although human troponin C1 (TNNC1) is expressed in both cardiac and skeletal muscle, duplication of this gene in zebrafish has resulted in tissue-specific partitioning of troponin C expression and function. Mutation of the… CONTINUE READING

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