Distinct transcriptomes define rostral and caudal serotonin neurons.

  title={Distinct transcriptomes define rostral and caudal serotonin neurons.},
  author={Christi J Wylie and Timothy J. Hendricks and Bing Zhang and Lily Wang and Pengcheng Lu and P. Michael Leahy and Stephanie M Fox and Hiroshi Maeno and Evan S Deneris},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 2},
The molecular architecture of developing serotonin (5HT) neurons is poorly understood, yet its determination is likely to be essential for elucidating functional heterogeneity of these cells and the contribution of serotonergic dysfunction to disease pathogenesis. Here, we describe the purification of postmitotic embryonic 5HT neurons by flow cytometry for whole-genome microarray expression profiling of this unitary monoaminergic neuron type. Our studies identified significantly enriched… CONTINUE READING