Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.

Abstract

Continued androgen receptor (AR) signaling is an established mechanism underlying castration-resistant prostate cancer (CRPC), and suppression of androgen receptor signaling remains a therapeutic goal of CRPC therapy. Constitutively active androgen receptor splice variants (AR-Vs) lack the androgen receptor ligand-binding domain (AR-LBD), the intended… (More)
DOI: 10.1158/0008-5472.CAN-11-3892

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Cite this paper

@article{Hu2012DistinctTP, title={Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.}, author={Rong Hu and Changxue Lu and Elahe A. Mostaghel and Srinivasan Thomas Yegnasubramanian and Meltem Gurel and Clare Tannahill and Joanne E Edwards and William B Isaacs and Peter S. Nelson and Eric G. Bluemn and Stephen R. Plymate and Jun Luo}, journal={Cancer research}, year={2012}, volume={72 14}, pages={3457-62} }