Distinct transcriptional mechanisms direct expression of the rat Dmrt1 promoter in sertoli cells and germ cells of transgenic mice.

@article{Lei2009DistinctTM,
  title={Distinct transcriptional mechanisms direct expression of the rat Dmrt1 promoter in sertoli cells and germ cells of transgenic mice.},
  author={Ning Lei and Tatiana Karpova and Kaori I Hornbaker and Daren A Rice and Leslie L. Heckert},
  journal={Biology of reproduction},
  year={2009},
  volume={81 1},
  pages={118-25}
}
DMRT1 is a transcription factor expressed only in Sertoli cells and undifferentiated spermatogonia of the postnatal testis, where it is required for proper cellular differentiation and fertility. To elucidate the transcriptional regulatory regions that provide DMRT1's cell-specific expression, transgenic mice containing a LacZ reporter gene driven by variable amounts of rat Dmrt1 5' flanking sequence, 9 kb and smaller, were evaluated. Examination of transgene expression by RT-PCR indicated that… CONTINUE READING
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