Distinct transcription start sites generate two forms of BRCA1 mRNA.

  title={Distinct transcription start sites generate two forms of BRCA1 mRNA.},
  author={C F Xu and Melissa A Brown and Jerome A. Chambers and Beatrice L. Griffiths and Hans Nicolai and E. Solomon},
  journal={Human molecular genetics},
  volume={4 12},
Using primer extension and 5' RACE, we have mapped the 5' end of the BRCA1 gene and identified a new 5' exon. Two distinct BRCA1 transcripts differing by the first exons were found; these transcripts were generated by the alternative use of dual promoters and alternative splicing. The expression of the distinct transcripts was examined in four primary tissues (placenta, mammary gland, testis and thymus), six normal or cancer cell lines, four primary breast tumor tissues and four primary ovary… CONTINUE READING


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