Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

@article{Gall2000DistinctTP,
  title={Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.},
  author={Sylvie Le Gall and Florence Buseyne and Alicja K. Trocha and Bruce D. Walker and Jean Michel Heard and Owen G Schwartz},
  journal={Journal of virology},
  year={2000},
  volume={74 19},
  pages={9256-66}
}
The human immunodeficiency virus type 1 Nef protein alters the post-Golgi stages of major histocompatibility complex class I (MHC-I) biogenesis. Presumed mechanisms involve the disclosure of a cryptic tyrosine-based sorting signal (YSQA) located in the cytoplasmic tail of HLA-A and -B heavy chains. We changed this signal for a prototypic sorting motif (YSQI or YSQL). Modified HLA-A2 molecules, termed A2-endo, displayed constitutively low surface levels and accumulated in a region close to or… CONTINUE READING
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