Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection.

Many Gram-positive pathogens link the expression of virulence genes to the presence of carbon source substrates using overlapping pathways for global control of carbon catabolite regulation. However, how these pathways are integrated to control the behavior of the transcriptome in time- and compartment-specific patterns is typically not well understood. In… CONTINUE READING