Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death

@article{Amantini2004DistinctTS,
  title={Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death},
  author={Consuelo Amantini and Michela Mosca and Roberta Lucciarini and Marina Cecilia Perfumi and Stefania Morrone and Matteo Beretta Piccoli and Gregory W. Santoni},
  journal={Cell Death and Differentiation},
  year={2004},
  volume={11},
  pages={1342-1356}
}
AbstractHerein, we provide the first evidence on the capsaicin (CPS) receptor vanilloid receptor type-1 (VR1) by rat thymocytes, and its involvement in CPS-induced apoptosis. VR1 mRNA was identified by quantitative RT-PCR in CD5+ thymocytes. By immunofluorescence and flow cytometry, we found that a substantial portion of CD5+ thymocytes, namely CD4+ and double negative (DN) cell subsets, express VR1 that was present on plasma membrane on discrete spots. By Western blot, VR1 protein was… CONTINUE READING
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