Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis

  title={Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis},
  author={Danuta Marona-Lewicka and Ronald A. Thisted and David E. Nichols},
RationaleThe effect of LSD in humans has been described as occurring in two temporal phases. The behavioral effects in rats also occur in two temporal phases: an initial suppression of exploration followed by increased locomotor activity.ObjectivesWe decided to investigate this phenomenon from the perspective that the pharmacology might have relevance to the neurochemical mechanisms underlying psychosis.MethodsTwenty-five male Sprague–Dawley rats were trained to discriminate LSD (186 nmol/kg, 0… 

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