Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI

@inproceedings{Pfeiler2016DistinctSP,
  title={Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI},
  author={Susanne Pfeiler and Avinash B. Khandagale and Astrid Magenau and Maryana Nichols and Harry F. G. Heijnen and Franz Rinninger and Tilman Ziegler and Stephanie M. Seveau and S{\"o}ren Schubert and Stefan Zahler and Admar Verschoor and Eicke Latz and Steffen Massberg and Katharina Gaus and Bernd Engelmann},
  booktitle={Scientific reports},
  year={2016}
}
The mechanisms protecting from immunopathology during acute bacterial infections are incompletely known. We found that in response to apoptotic immune cells and live or dead Listeria monocytogenes scavenger receptor BI (SR-BI), an anti-atherogenic lipid exchange mediator, activated internalization mechanisms with characteristics of macropinocytosis and, assisted by Golgi fragmentation, initiated autophagic responses. This was supported by scavenger receptor-induced local increases in membrane… CONTINUE READING

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