Distinct subpopulations of epithelial ovarian cancer cells can differentially induce macrophages and T regulatory cells toward a pro-tumor phenotype.

@article{Alvero2012DistinctSO,
  title={Distinct subpopulations of epithelial ovarian cancer cells can differentially induce macrophages and T regulatory cells toward a pro-tumor phenotype.},
  author={Ayesha B. Alvero and Michele K. Montagna and Vinicius Craveiro and Lanzhen Liu and Gil Mor},
  journal={American journal of reproductive immunology},
  year={2012},
  volume={67 3},
  pages={256-65}
}
PROBLEM Presence of immune infiltrates in the tumor does not always correlate with an anti-tumoral immune response. We previously identified two subpopulations of epithelial ovarian cancer (EOC) cells with differential cytokine profile. We hypothesize that these two subpopulations of EOC cells may differentially regulate the immune phenotype in the tumor microenvironment and therefore affect the immune response. METHOD OF STUDY Macrophages derived from CD14+ monocytes and naive CD4+T cells… CONTINUE READING
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