Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands.

@article{Li2007DistinctSC,
  title={Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands.},
  author={Jian Hua Li and Sung-jun Han and Fadi Hamdan and Soo-Kyung Kim and Kenneth A. Jacobson and Lanh M Bloodworth and Xiaohong Mary Zhang and Juergen Wess},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 36},
  pages={26284-93}
}
The activity of G protein-coupled receptors can be modulated by different classes of ligands, including agonists that promote receptor signaling and inverse agonists that reduce basal receptor activity. The conformational changes in receptor structure induced by different agonist ligands are not well understood at present. In this study, we employed an in situ disulfide cross-linking strategy to monitor ligand-induced conformational changes in a series of cysteine-substituted mutant M(3… CONTINUE READING

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