Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome.

@article{Dahl2006DistinctSA,
  title={Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome.},
  author={Kris Noel Dahl and Paola Scaffidi and Mohammad F Islam and A. G. Yodh and Katherine L. Wilson and Tom Misteli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 27},
  pages={10271-10276}
}
The nuclear lamina is a network of structural filaments, the A and B type lamins, located at the nuclear envelope and throughout the nucleus. Lamin filaments provide the nucleus with mechanical stability and support many basic activities, including gene regulation. Mutations in LMNA, the gene encoding A type lamins, cause numerous human diseases, including the segmental premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Here we show that structural and mechanical properties of… CONTINUE READING

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Principles of Condensed Matter Physics

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