Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins

@article{Phua2013DistinctSO,
  title={Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins},
  author={Yu Leng Phua and Nick Martel and David J. Pennisi and Melissa H. Little and Lorine Wilkinson},
  journal={The Journal of Pathology},
  year={2013},
  volume={229}
}
Crim1 is a transmembrane protein that regulates the bioavailability of growth factors such as VEGFA. Crim1KST264/KST264 hypomorphic mice develop renal disease characterized by glomerular cysts and loss of endothelial integrity, progressing to peritubular and pericystic fibrosis. Peritubular capillary endothelial cells display morphological changes as well as detachment from the basement membrane. In this study, gene expression profiling of CD31+ endothelial cells isolated from Crim1KST264… Expand
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