Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.

  title={Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.},
  author={M Park-Chung and Felix S. Wu and Robert H. Purdy and Andrew Malayev and Terrell T. Gibbs and David H. Farb},
  journal={Molecular pharmacology},
  volume={52 6},
Steroid sulfation occurs in nervous tissue and endogenous sulfated steroids can act as positive or negative modulators of N-methyl-D-aspartate (NMDA) receptor function. In the current study, structure-activity relationships for sulfated steroids were examined in voltage-clamped chick spinal cord and rat hippocampal neurons in culture and in Xenopus laevis oocytes expressing NR1(100) and NR2A subunits. The ability of pregnenolone sulfate (a positive modulator) and epipregnanolone sulfate (a… CONTINUE READING


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