Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.

@article{ParkChung1997DistinctSF,
  title={Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.},
  author={M Park-Chung and Felix S. Wu and Robert H. Purdy and Andrew Malayev and Terrell T. Gibbs and David H. Farb},
  journal={Molecular pharmacology},
  year={1997},
  volume={52 6},
  pages={1113-23}
}
Steroid sulfation occurs in nervous tissue and endogenous sulfated steroids can act as positive or negative modulators of N-methyl-D-aspartate (NMDA) receptor function. In the current study, structure-activity relationships for sulfated steroids were examined in voltage-clamped chick spinal cord and rat hippocampal neurons in culture and in Xenopus laevis oocytes expressing NR1(100) and NR2A subunits. The ability of pregnenolone sulfate (a positive modulator) and epipregnanolone sulfate (a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Pregnanolone isomers, pregnenolone and their polar conjugates around parturition.

Physiological research • 2003
View 10 Excerpts
Highly Influenced

Pregnanolone sulfate promotes desensitization of activated NMDA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 51 references

advantages of a sandwich culture technique or low oxygen

G. J. Brewer, C. W. Cotman. Survival, growth of hippocampal neurons in defined medium at low density
Brain Res. 494:65–74 • 1989
View 4 Excerpts
Highly Influenced

selective binding to open channels

J. E. Huettner, B. P. Bean. Block of N-methyl-D-aspartate-activated c MK-801
Proc. Natl. Acad. Sci. USA 85:1307–1311 • 1988
View 9 Excerpts
Highly Influenced

a positive allosteric modulator at the NMDA receptor

Wu, F.-S., T. T. Gibbs, D. H. Farb. Pregnenolone sulfate
Mol. Pharmacol. 40:333–336 • 1991
View 7 Excerpts
Highly Influenced

The effects of neuroactive steroids on recombinant NMDA receptors

N. Yaghoubi, A. A. Malayev, T. T. Gibbs, D. H. Farb
Soc. Neurosci. Abstr • 1996
View 1 Excerpt

Dehydroepiandrosterone sulfate and aging.

Annals of the New York Academy of Sciences • 1995
View 1 Excerpt

Similar Papers

Loading similar papers…