Distinct single-cell morphological dynamics under beta-lactam antibiotics.

@article{Yao2012DistinctSM,
  title={Distinct single-cell morphological dynamics under beta-lactam antibiotics.},
  author={Zhizhong Yao and Daniel E Kahne and Roy Kishony},
  journal={Molecular cell},
  year={2012},
  volume={48 5},
  pages={705-12}
}
The bacterial cell wall is conserved in prokaryotes, stabilizing cells against osmotic stress. Beta-lactams inhibit cell-wall synthesis and induce lysis through a bulge-mediated mechanism; however, little is known about the formation dynamics and stability of these bulges. To capture processes of different timescales, we developed an imaging platform combining automated image analysis with live-cell microscopy at high time resolution. Beta-lactam killing of Escherichia coli cells proceeded… CONTINUE READING
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