Distinct saturable pathways for the endocytosis of different tyrosine motifs.

@article{Warren1998DistinctSP,
  title={Distinct saturable pathways for the endocytosis of different tyrosine motifs.},
  author={Richard A. J. Warren and Frank A Green and Paula E. Stenberg and Caroline A Enns},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 27},
  pages={17056-63}
}
Endocytosis of surface proteins through clathrin-coated pits requires an internalization signal in the cytoplasmic domain. Two types of internalization signal have been described: one requiring a tyrosine as the critical residue (tyrosine-based motif), and the other consisting of either two consecutive leucines or an isoleucine and leucine (dileucine motif). Although it seems that these signals are necessary and sufficient for endocytic targeting, the mechanism of recognition is not well… CONTINUE READING