Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice.

@article{Morio2001DistinctRO,
  title={Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice.},
  author={Lisa A Morio and Hawjyh Chiu and K A Sprowles and Peihong Zhou and Diane E. Heck and M. K. Gordon and Debra L. Laskin},
  journal={Toxicology and applied pharmacology},
  year={2001},
  volume={172 1},
  pages={44-51}
}
Macrophages are known to release a number of different inflammatory mediators with cytotoxic potential. In the present studies we analyzed the role of two macrophage-derived mediators, tumor necrosis factor-alpha (TNF-alpha) and nitric oxide, in liver injury induced by carbon tetrachloride (CCl4). Treatment of mice with CCl4 resulted in a dose- and time-dependent induction of centrilobular hepatic necrosis. This was observed within 12 h with 0.3 ml/kg CCl4 and was correlated with increases in… CONTINUE READING

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