Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom-induced pain behaviors.

  title={Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom-induced pain behaviors.},
  author={L-Y Ren and Z Lu and M Liu and Y Yu and Z Li and G L Shang and J Chen},
  volume={153 1},
A wide variety of human and animal experiments suggest that the anterior cingulate cortex (ACC) is one of the key brain substrates subserving higher order processing of noxious information. However, no sufficient data are now available regarding the mediation by ACC of different levels of pain processing as well as its potential descending modulation of spinal nociception. Using the well-developed rat bee venom (BV) model, the present study evaluated the effect of lesions of bilateral ACC on… CONTINUE READING

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