Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control.

@article{Aizaki2009DistinctRO,
  title={Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control.},
  author={Yoshimi Aizaki and Kei Maruyama and Mitsue Nakano-Tetsuka and Yumiko Saito},
  journal={Peptides},
  year={2009},
  volume={30 5},
  pages={974-81}
}
Rhodopsin family (class A) G protein-coupled receptors possess common key residues or motifs that appear to be important for receptor function. To clarify the roles of the highly conserved amino acid triplet Asp(3.49)-Arg(3.50)-Tyr(3.51) (DRY motif), we examined how single-substitution mutations of the amino acids in the motif influenced specific features of rat melanin-concentrating hormone receptor 1 (MCH1R) activity. Substitution of either Asp140(3.49) or Tyr142(3.51) to Ala resulted in… CONTINUE READING

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Role of asparagine-linked oligosaccharides in the function of the melanin-concentrating hormone (MCH) receptor

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Highly Influenced

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