Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.

@article{Jeyaseelan2005DistinctRO,
  title={Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.},
  author={Samithamby Jeyaseelan and Hong Wei Chu and Scott K. Young and Mason Wright Freeman and George Scott Worthen},
  journal={Infection and immunity},
  year={2005},
  volume={73 3},
  pages={
          1754-63
        }
}
Acute lung injury (ALI) induced by lipopolysaccharide (LPS) is a major cause of mortality among humans. ALI is characterized by microvascular protein leakage, neutrophil influx, and expression of proinflammatory mediators, followed by severe lung damage. LPS binding to its receptors is the crucial step in the causation of these multistep events. LPS binding and signaling involves CD14 and Toll-like receptor 4 (TLR4). However, the relative contributions of CD14 and TLR4 in the induction of ALI… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation

J. A. Nick, S. K. Young, +8 authors G. S. Worthen
  • J. Immunol
  • 2002
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.

  • American journal of respiratory and critical care medicine
  • 2001
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

LPS-binding proteins and receptors.

  • Journal of leukocyte biology
  • 1998
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Hemorrhage-induced acute lung injury is TLR-4 dependent.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2004
VIEW 1 EXCERPT

Effect of CD14 blockade on endotoxin-induced acute lung injury in mice.

  • American journal of respiratory cell and molecular biology
  • 2003
VIEW 2 EXCERPTS

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