Distinct roles of neuropilin 1 signaling for radial and tangential extension of callosal axons.

@article{Hatanaka2009DistinctRO,
  title={Distinct roles of neuropilin 1 signaling for radial and tangential extension of callosal axons.},
  author={Yumiko Hatanaka and Tomoko Matsumoto and Yuchio Yanagawa and Hajime Fujisawa and Fujio Murakami and Masayuki Masu},
  journal={The Journal of comparative neurology},
  year={2009},
  volume={514 3},
  pages={215-25}
}
Cortical excitatory neurons migrate from their origin in the ventricular zone (VZ) toward the pial surface. During migration, these neurons exhibit a stellate shape in the intermediate zone (IZ), transform into bipolar cells, and then initiate radial migration, extending a trailing process, which may lead to an axon. Here we examined the role of neuropilin 1 (NRP1) in these developmental events. Both NRP1 mRNA and protein were highly expressed in the IZ, where stellate-shaped cells were located… CONTINUE READING

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